MetNetComp Database [1] / Minimal gene deletions Minimal gene deletions for simulation-based growth-coupled production. You can also see maximal gene deletions.

Model : STM_v1_0 [2].
Target metabolite : 12dgr120_p
List of minimal gene deletion strategies (Download)

Gene deletion strategy (32 of 110: See next) for growth-coupled production (at least stoichioemetrically feasible)
  Gene deletion size : 33
  Gene deletion: STM2927 STM1749 STM2463 STM2285 STM3526 STM0322 STM1290 STM4326 STM1511 STM1884 STM2947 STM3709 STM3068 STM2141 STM1620 STM0370 STM1448 STM0518 STM4184 STM4484 STM2317 STM3179 STM4569 STM1480 STM4126 STM2338 STM2466 STM4467 STM2196 STM3240 STM3708 STM2971 STM1826   (List of alternative genes)
  Computed by: RandTrimGdel [1] (Step 1, Step 2)

When growth rate is maximized,
  Growth Rate : 0.069476 (mmol/gDw/h)
  Minimum Production Rate : 0.079047 (mmol/gDw/h)

Substrate: (mmol/gDw/h)
  EX_o2_e : 9.128276
  EX_glc__D_e : 5.000000
  EX_nh4_e : 0.765632
  EX_pi_e : 0.061612
  EX_k_e : 0.012339
  EX_so4_e : 0.008475
  EX_mg2_e : 0.000549
  EX_fe2_e : 0.000508
  EX_ca2_e : 0.000329
  EX_cl_e : 0.000329
  EX_cobalt2_e : 0.000219
  EX_cu2_e : 0.000219
  EX_mn2_e : 0.000219
  EX_mobd_e : 0.000219
  EX_zn2_e : 0.000219

Product: (mmol/gDw/h)
  EX_h2o_e : 12.020487
  EX_co2_e : 10.026115
  EX_dha_e : 4.930219
  EX_h_e : 0.592464
  EX_acald_e : 0.177249
  Auxiliary production reaction : 0.079047
  EX_glyclt_e : 0.003474
  DM_hmfurn_c : 0.000031

Visualization
  1. Download JSON file.
  2. Go to Escher site [3].

References
[1] Tamura, T. MetNetComp: Database for minimal and maximal gene deletion strategies for growth-coupled production of genome-scale metabolic networks, IEEE/ACM Transactions on Computational Biology and Bioinformatics, in press.
[2] Norsigian, C. J., Pusarla, N., McConn, J. L., Yurkovich, J. T., Dräger, A., Palsson, B. O., & King, Z. (2020). BiGG Models 2020: multi-strain genome-scale models and expansion across the phylogenetic tree. Nucleic acids research, 48(D1), D402-D406.
[3] King, Z. A., Dräger, A., Ebrahim, A., Sonnenschein, N., Lewis, N. E., & Palsson, B. O. (2015). Escher: a web application for building, sharing, and embedding data-rich visualizations of biological pathways. PLoS computational biology, 11(8), e1004321.

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Last updated: 27-Sep-2023
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