MetNetComp Database [1] / Minimal gene deletions

Minimal gene deletions for simulation-based growth-coupled production. You can also see maximal gene deletions.

Model : STM_v1_0 [2].
Target metabolite : ddca_p
List of minimal gene deletion strategies (Download)

Gene deletion strategy (33 of 113: See next) for growth-coupled production (at least stoichioemetrically feasible)
  Gene deletion size : 35
  Gene deletion: STM2927 STM1749 STM2463 STM2285 STM3526 STM0322 STM4326 STM1511 STM2952 STM2947 STM3709 STM3068 STM2141 STM1570 STM1620 STM4036 STM0368 STM1448 STM0518 STM4184 STM4484 STM2317 STM3179 STM4569 STM1480 STM4126 STM2338 STM2466 STM0977 STM4467 STM2196 STM3240 STM3708 STM2971 STM1826   (List of alternative genes)
  Computed by: RandTrimGdel [1] (Step 1, Step 2)

When growth rate is maximized,
  Growth Rate : 0.277211 (mmol/gDw/h)
  Minimum Production Rate : 0.013539 (mmol/gDw/h)

 Substrate: (mmol/gDw/h)
  EX_o2_e : 17.333726
  EX_glc__D_e : 5.000000
  EX_nh4_e : 3.054900
  EX_pi_e : 0.245837
  EX_k_e : 0.049233
  EX_so4_e : 0.033815
  EX_mg2_e : 0.002189
  EX_fe2_e : 0.002032
  EX_ca2_e : 0.001313
  EX_cl_e : 0.001313
  EX_cobalt2_e : 0.000875
  EX_cu2_e : 0.000875
  EX_mn2_e : 0.000875
  EX_mobd_e : 0.000875
  EX_zn2_e : 0.000875

Product: (mmol/gDw/h)
  EX_h2o_e : 25.314337
  EX_co2_e : 17.672108
  EX_h_e : 2.377486
  EX_acald_e : 0.707229
  EX_glyclt_e : 0.013861
  Auxiliary production reaction : 0.013539
  DM_hmfurn_c : 0.000124

Visualization
  1. Download JSON file.
  2. Go to Escher site [3].

References
[1] Tamura, T. MetNetComp: Database for minimal and maximal gene deletion strategies for growth-coupled production of genome-scale metabolic networks, IEEE/ACM Transactions on Computational Biology and Bioinformatics, in press.
[2] Norsigian, C. J., Pusarla, N., McConn, J. L., Yurkovich, J. T., Dräger, A., Palsson, B. O., & King, Z. (2020). BiGG Models 2020: multi-strain genome-scale models and expansion across the phylogenetic tree. Nucleic acids research, 48(D1), D402-D406.
[3] King, Z. A., Dräger, A., Ebrahim, A., Sonnenschein, N., Lewis, N. E., & Palsson, B. O. (2015). Escher: a web application for building, sharing, and embedding data-rich visualizations of biological pathways. PLoS computational biology, 11(8), e1004321.

Last updated: 27-Sep-2023
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