MetNetComp Database [1] / Minimal gene deletions

Minimal gene deletions for simulation-based growth-coupled production. You can also see maximal gene deletions.

Model : STM_v1_0 [2].
Target metabolite : fgam_c
List of minimal gene deletion strategies (Download)

Gene deletion strategy (110 of 114: See next) for growth-coupled production (at least stoichioemetrically feasible)
  Gene deletion size : 25
  Gene deletion: STM3010 STM2927 STM2421 STM1749 STM2463 STM4275 STM2009 STM4568 STM1511 STM3709 STM0974 STM0152 STM0150 STM2338 STM2466 STM2332 STM3968 STM0208 STM2498 STM2196 STM3240 STM2970 STM3243 STM2971 STM1826   (List of alternative genes)
  Computed by: RandTrimGdel [1] (Step 1, Step 2)

When growth rate is maximized,
  Growth Rate : 0.321600 (mmol/gDw/h)
  Minimum Production Rate : 0.494261 (mmol/gDw/h)

 Substrate: (mmol/gDw/h)
  EX_o2_e : 11.356936
  EX_glc__D_e : 5.000000
  EX_nh4_e : 4.542174
  EX_pi_e : 0.779464
  EX_k_e : 0.057116
  EX_so4_e : 0.039229
  EX_mg2_e : 0.002539
  EX_fe2_e : 0.002357
  EX_ca2_e : 0.001523
  EX_cl_e : 0.001523
  EX_cobalt2_e : 0.001016
  EX_cu2_e : 0.001016
  EX_mn2_e : 0.001016
  EX_mobd_e : 0.001016
  EX_zn2_e : 0.001016

Product: (mmol/gDw/h)
  EX_h2o_e : 22.127342
  EX_co2_e : 10.768524
  EX_h_e : 5.137039
  EX_ac_e : 1.412537
  Auxiliary production reaction : 0.494261
  EX_hxan_e : 0.002395
  DM_hmfurn_c : 0.000143

Visualization
  1. Download JSON file.
  2. Go to Escher site [3].

References
[1] Tamura, T. MetNetComp: Database for minimal and maximal gene deletion strategies for growth-coupled production of genome-scale metabolic networks, IEEE/ACM Transactions on Computational Biology and Bioinformatics, in press.
[2] Norsigian, C. J., Pusarla, N., McConn, J. L., Yurkovich, J. T., Dräger, A., Palsson, B. O., & King, Z. (2020). BiGG Models 2020: multi-strain genome-scale models and expansion across the phylogenetic tree. Nucleic acids research, 48(D1), D402-D406.
[3] King, Z. A., Dräger, A., Ebrahim, A., Sonnenschein, N., Lewis, N. E., & Palsson, B. O. (2015). Escher: a web application for building, sharing, and embedding data-rich visualizations of biological pathways. PLoS computational biology, 11(8), e1004321.

Last updated: 27-Sep-2023
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