MetNetComp Database [1] / Minimal gene deletions

Minimal gene deletions for simulation-based growth-coupled production. You can also see maximal gene deletions.

Model : STM_v1_0 [2].
Target metabolite : pa120_p
List of minimal gene deletion strategies (Download)

Gene deletion strategy (33 of 130: See next) for growth-coupled production (at least stoichioemetrically feasible)
  Gene deletion size : 26
  Gene deletion: STM3646 STM1749 STM2463 STM2285 STM3526 STM0322 STM4567 STM4326 STM0517 STM2947 STM3709 STM1135 STM3542 STM4485 STM4183 STM0369 STM1448 STM1326 STM4062 STM3069 STM4484 STM2317 STM3179 STM1480 STM4126 STM3708   (List of alternative genes)
  Computed by: RandTrimGdel [1] (Step 1, Step 2)

When growth rate is maximized,
  Growth Rate : 0.189534 (mmol/gDw/h)
  Minimum Production Rate : 0.102037 (mmol/gDw/h)

 Substrate: (mmol/gDw/h)
  EX_o2_e : 18.500000
  EX_glc__D_e : 5.000000
  EX_nh4_e : 2.088693
  EX_pi_e : 0.270121
  EX_k_e : 0.033661
  EX_so4_e : 0.023120
  EX_mg2_e : 0.001496
  EX_fe2_e : 0.001389
  EX_ca2_e : 0.000898
  EX_cl_e : 0.000898
  EX_cobalt2_e : 0.000599
  EX_cu2_e : 0.000599
  EX_mn2_e : 0.000599
  EX_mobd_e : 0.000599
  EX_zn2_e : 0.000599

Product: (mmol/gDw/h)
  EX_h2o_e : 25.019835
  EX_co2_e : 19.590625
  EX_h_e : 1.616276
  EX_acald_e : 0.151866
  Auxiliary production reaction : 0.102037
  EX_glyclt_e : 0.009477
  DM_hmfurn_c : 0.000085

Visualization
  1. Download JSON file.
  2. Go to Escher site [3].

References
[1] Tamura, T. MetNetComp: Database for minimal and maximal gene deletion strategies for growth-coupled production of genome-scale metabolic networks, IEEE/ACM Transactions on Computational Biology and Bioinformatics, in press.
[2] Norsigian, C. J., Pusarla, N., McConn, J. L., Yurkovich, J. T., Dräger, A., Palsson, B. O., & King, Z. (2020). BiGG Models 2020: multi-strain genome-scale models and expansion across the phylogenetic tree. Nucleic acids research, 48(D1), D402-D406.
[3] King, Z. A., Dräger, A., Ebrahim, A., Sonnenschein, N., Lewis, N. E., & Palsson, B. O. (2015). Escher: a web application for building, sharing, and embedding data-rich visualizations of biological pathways. PLoS computational biology, 11(8), e1004321.

Last updated: 27-Sep-2023
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