MetNetComp Database [1] / Minimal gene deletions Minimal gene deletions for simulation-based growth-coupled production. You can also see maximal gene deletions.

Model : STM_v1_0 [2].
Target metabolite : pa140_c
List of minimal gene deletion strategies (Download)

Gene deletion strategy (41 of 43: See next) for growth-coupled production (at least stoichioemetrically feasible)
  Gene deletion size : 37
  Gene deletion: STM2927 STM1749 STM2463 STM2285 STM3526 STM0322 STM4326 STM1511 STM1885 STM2947 STM3709 STM3068 STM2141 STM1620 STM0370 STM3597 STM4408 STM1291 STM3069 STM4184 STM4484 STM2317 STM3179 STM4569 STM1480 STM4126 STM2338 STM2466 STM3248 STM0519 STM4467 STM2196 STM3240 STM0402 STM0608 STM2971 STM1826   (List of alternative genes)
  Computed by: RandTrimGdel [1] (Step 1, Step 2)

When growth rate is maximized,
  Growth Rate : 0.071151 (mmol/gDw/h)
  Minimum Production Rate : 0.065802 (mmol/gDw/h)

Substrate: (mmol/gDw/h)
  EX_o2_e : 9.160097
  EX_glc__D_e : 5.000000
  EX_nh4_e : 0.784087
  EX_pi_e : 0.128898
  EX_k_e : 0.012636
  EX_so4_e : 0.008679
  EX_mg2_e : 0.000562
  EX_fe2_e : 0.000521
  EX_ca2_e : 0.000337
  EX_cl_e : 0.000337
  EX_cobalt2_e : 0.000225
  EX_cu2_e : 0.000225
  EX_mn2_e : 0.000225
  EX_mobd_e : 0.000225
  EX_zn2_e : 0.000225

Product: (mmol/gDw/h)
  EX_h2o_e : 12.145191
  EX_co2_e : 10.052094
  EX_dha_e : 4.928537
  EX_h_e : 0.606744
  EX_acald_e : 0.181521
  Auxiliary production reaction : 0.065802
  EX_glyclt_e : 0.003558
  DM_hmfurn_c : 0.000032

Visualization
  1. Download JSON file.
  2. Go to Escher site [3].

References
[1] Tamura, T. MetNetComp: Database for minimal and maximal gene deletion strategies for growth-coupled production of genome-scale metabolic networks, IEEE/ACM Transactions on Computational Biology and Bioinformatics, in press.
[2] Norsigian, C. J., Pusarla, N., McConn, J. L., Yurkovich, J. T., Dräger, A., Palsson, B. O., & King, Z. (2020). BiGG Models 2020: multi-strain genome-scale models and expansion across the phylogenetic tree. Nucleic acids research, 48(D1), D402-D406.
[3] King, Z. A., Dräger, A., Ebrahim, A., Sonnenschein, N., Lewis, N. E., & Palsson, B. O. (2015). Escher: a web application for building, sharing, and embedding data-rich visualizations of biological pathways. PLoS computational biology, 11(8), e1004321.

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Last updated: 27-Sep-2023
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