MetNetComp Database [1] / Minimal gene deletions Minimal gene deletions for simulation-based growth-coupled production. You can also see maximal gene deletions.

Model : STM_v1_0 [2].
Target metabolite : pa160_c
List of minimal gene deletion strategies (Download)

Gene deletion strategy (31 of 85: See next) for growth-coupled production (at least stoichioemetrically feasible)
  Gene deletion size : 27
  Gene deletion: STM3646 STM2285 STM3526 STM0169 STM0861 STM4326 STM1511 STM2952 STM1135 STM4183 STM0974 STM1448 STM1326 STM4062 STM3062 STM4484 STM2317 STM3179 STM4569 STM1480 STM4126 STM1124 STM2196 STM3240 STM2051 STM2971 STM1826   (List of alternative genes)
  Computed by: RandTrimGdel [1] (Step 1, Step 2)

When growth rate is maximized,
  Growth Rate : 0.212358 (mmol/gDw/h)
  Minimum Production Rate : 0.067281 (mmol/gDw/h)

Substrate: (mmol/gDw/h)
  EX_o2_e : 18.500000
  EX_glc__D_e : 5.000000
  EX_nh4_e : 2.340209
  EX_pi_e : 0.255604
  EX_k_e : 0.037715
  EX_so4_e : 0.025904
  EX_mg2_e : 0.001677
  EX_fe2_e : 0.001556
  EX_ca2_e : 0.001006
  EX_cl_e : 0.001006
  EX_cobalt2_e : 0.000671
  EX_cu2_e : 0.000671
  EX_mn2_e : 0.000671
  EX_mobd_e : 0.000671
  EX_zn2_e : 0.000671

Product: (mmol/gDw/h)
  EX_h2o_e : 25.403596
  EX_co2_e : 19.414697
  EX_h_e : 1.805596
  Auxiliary production reaction : 0.067281
  EX_glyc__R_e : 0.005309
  DM_hmfurn_c : 0.000095

Visualization
  1. Download JSON file.
  2. Go to Escher site [3].

References
[1] Tamura, T. MetNetComp: Database for minimal and maximal gene deletion strategies for growth-coupled production of genome-scale metabolic networks, IEEE/ACM Transactions on Computational Biology and Bioinformatics, in press.
[2] Norsigian, C. J., Pusarla, N., McConn, J. L., Yurkovich, J. T., Dräger, A., Palsson, B. O., & King, Z. (2020). BiGG Models 2020: multi-strain genome-scale models and expansion across the phylogenetic tree. Nucleic acids research, 48(D1), D402-D406.
[3] King, Z. A., Dräger, A., Ebrahim, A., Sonnenschein, N., Lewis, N. E., & Palsson, B. O. (2015). Escher: a web application for building, sharing, and embedding data-rich visualizations of biological pathways. PLoS computational biology, 11(8), e1004321.

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Last updated: 27-Sep-2023
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