MetNetComp Database [1] / Minimal gene deletions

Minimal gene deletions for simulation-based growth-coupled production. You can also see maximal gene deletions.

Model : STM_v1_0 [2].
Target metabolite : pa161_c
List of minimal gene deletion strategies (Download)

Gene deletion strategy (23 of 113: See next) for growth-coupled production (at least stoichioemetrically feasible)
  Gene deletion size : 25
  Gene deletion: STM3646 STM2285 STM3526 STM1290 STM0169 STM0861 STM4326 STM1511 STM0840 STM0842 STM0517 STM1135 STM4183 STM0370 STM1448 STM4484 STM2317 STM3179 STM1480 STM4126 STM2338 STM2466 STM1124 STM0007 STM2473   (List of alternative genes)
  Computed by: RandTrimGdel [1] (Step 1, Step 2)

When growth rate is maximized,
  Growth Rate : 0.251027 (mmol/gDw/h)
  Minimum Production Rate : 0.034859 (mmol/gDw/h)

 Substrate: (mmol/gDw/h)
  EX_o2_e : 18.500000
  EX_glc__D_e : 5.000000
  EX_nh4_e : 2.766347
  EX_pi_e : 0.257476
  EX_k_e : 0.044582
  EX_so4_e : 0.030621
  EX_mg2_e : 0.001982
  EX_fe2_e : 0.001840
  EX_ca2_e : 0.001189
  EX_cl_e : 0.001189
  EX_cu2_e : 0.000793
  EX_mn2_e : 0.000793
  EX_mobd_e : 0.000793
  EX_zn2_e : 0.000793
  EX_cobalt2_e : 0.000793

Product: (mmol/gDw/h)
  EX_h2o_e : 25.955320
  EX_co2_e : 18.895508
  EX_h_e : 2.215129
  EX_ac_e : 0.074470
  Auxiliary production reaction : 0.034859
  EX_glyclt_e : 0.012551
  DM_hmfurn_c : 0.000112

Visualization
  1. Download JSON file.
  2. Go to Escher site [3].

References
[1] Tamura, T. MetNetComp: Database for minimal and maximal gene deletion strategies for growth-coupled production of genome-scale metabolic networks, IEEE/ACM Transactions on Computational Biology and Bioinformatics, in press.
[2] Norsigian, C. J., Pusarla, N., McConn, J. L., Yurkovich, J. T., Dräger, A., Palsson, B. O., & King, Z. (2020). BiGG Models 2020: multi-strain genome-scale models and expansion across the phylogenetic tree. Nucleic acids research, 48(D1), D402-D406.
[3] King, Z. A., Dräger, A., Ebrahim, A., Sonnenschein, N., Lewis, N. E., & Palsson, B. O. (2015). Escher: a web application for building, sharing, and embedding data-rich visualizations of biological pathways. PLoS computational biology, 11(8), e1004321.

Last updated: 27-Sep-2023
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