MetNetComp Database [1] / Minimal gene deletions

Minimal gene deletions for simulation-based growth-coupled production. You can also see maximal gene deletions.

Model : STM_v1_0 [2].
Target metabolite : pa180_c
List of minimal gene deletion strategies (Download)

Gene deletion strategy (25 of 113: See next) for growth-coupled production (at least stoichioemetrically feasible)
  Gene deletion size : 25
  Gene deletion: STM3646 STM4108 STM2285 STM3526 STM4326 STM1511 STM1885 STM0517 STM3529 STM1135 STM4183 STM0368 STM1448 STM3069 STM4484 STM2317 STM3179 STM4569 STM1480 STM4126 STM1124 STM2196 STM3240 STM2971 STM1826   (List of alternative genes)
  Computed by: RandTrimGdel [1] (Step 1, Step 2)

When growth rate is maximized,
  Growth Rate : 0.256290 (mmol/gDw/h)
  Minimum Production Rate : 0.029487 (mmol/gDw/h)

 Substrate: (mmol/gDw/h)
  EX_o2_e : 18.500000
  EX_glc__D_e : 5.000000
  EX_nh4_e : 2.824354
  EX_pi_e : 0.256771
  EX_k_e : 0.045517
  EX_so4_e : 0.031263
  EX_mg2_e : 0.002023
  EX_fe2_e : 0.001878
  EX_ca2_e : 0.001214
  EX_cl_e : 0.001214
  EX_cobalt2_e : 0.000809
  EX_cu2_e : 0.000809
  EX_mn2_e : 0.000809
  EX_mobd_e : 0.000809
  EX_zn2_e : 0.000809

Product: (mmol/gDw/h)
  EX_h2o_e : 26.034326
  EX_co2_e : 18.909864
  EX_h_e : 2.185547
  Auxiliary production reaction : 0.029487
  EX_glyclt_e : 0.012815
  EX_glyald_e : 0.000178
  DM_hmfurn_c : 0.000114

Visualization
  1. Download JSON file.
  2. Go to Escher site [3].

References
[1] Tamura, T. MetNetComp: Database for minimal and maximal gene deletion strategies for growth-coupled production of genome-scale metabolic networks, IEEE/ACM Transactions on Computational Biology and Bioinformatics, in press.
[2] Norsigian, C. J., Pusarla, N., McConn, J. L., Yurkovich, J. T., Dräger, A., Palsson, B. O., & King, Z. (2020). BiGG Models 2020: multi-strain genome-scale models and expansion across the phylogenetic tree. Nucleic acids research, 48(D1), D402-D406.
[3] King, Z. A., Dräger, A., Ebrahim, A., Sonnenschein, N., Lewis, N. E., & Palsson, B. O. (2015). Escher: a web application for building, sharing, and embedding data-rich visualizations of biological pathways. PLoS computational biology, 11(8), e1004321.

Last updated: 27-Sep-2023
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