MetNetComp Database [1] / Minimal gene deletions

Minimal gene deletions for simulation-based growth-coupled production. You can also see maximal gene deletions.

Model : STM_v1_0 [2].
Target metabolite : pphn_c
List of minimal gene deletion strategies (Download)

Gene deletion strategy (37 of 65: See next) for growth-coupled production (at least stoichioemetrically feasible)
  Gene deletion size : 17
  Gene deletion: STM1749 STM2463 STM1570 STM1620 STM4036 STM2167 STM3542 STM4485 STM0785 STM1211 STM2317 STM0935 STM1480 STM2051 STM0733 STM0007 STM2473   (List of alternative genes)
  Computed by: RandTrimGdel [1] (Step 1, Step 2)

When growth rate is maximized,
  Growth Rate : 0.063188 (mmol/gDw/h)
  Minimum Production Rate : 0.043408 (mmol/gDw/h)

 Substrate: (mmol/gDw/h)
  EX_glc__D_e : 5.000000
  EX_o2_e : 4.290652
  EX_nh4_e : 0.696335
  EX_co2_e : 0.057568
  EX_pi_e : 0.056035
  EX_k_e : 0.011222
  EX_so4_e : 0.007708
  EX_mg2_e : 0.000499
  EX_fe2_e : 0.000463
  EX_ca2_e : 0.000299
  EX_cl_e : 0.000299
  EX_cobalt2_e : 0.000200
  EX_cu2_e : 0.000200
  EX_mn2_e : 0.000200
  EX_mobd_e : 0.000200
  EX_zn2_e : 0.000200

Product: (mmol/gDw/h)
  EX_h_e : 18.218350
  EX_for_e : 8.615232
  EX_ac_e : 8.374717
  EX_h2o_e : 1.901442
  EX_lac__D_e : 0.602747
  Auxiliary production reaction : 0.043408
  EX_glyclt_e : 0.003159
  DM_hmfurn_c : 0.000028

Visualization
  1. Download JSON file.
  2. Go to Escher site [3].

References
[1] Tamura, T. MetNetComp: Database for minimal and maximal gene deletion strategies for growth-coupled production of genome-scale metabolic networks, IEEE/ACM Transactions on Computational Biology and Bioinformatics, in press.
[2] Norsigian, C. J., Pusarla, N., McConn, J. L., Yurkovich, J. T., Dräger, A., Palsson, B. O., & King, Z. (2020). BiGG Models 2020: multi-strain genome-scale models and expansion across the phylogenetic tree. Nucleic acids research, 48(D1), D402-D406.
[3] King, Z. A., Dräger, A., Ebrahim, A., Sonnenschein, N., Lewis, N. E., & Palsson, B. O. (2015). Escher: a web application for building, sharing, and embedding data-rich visualizations of biological pathways. PLoS computational biology, 11(8), e1004321.

Last updated: 27-Sep-2023
Contact