MetNetComp Database [1] / Core Genes

A set of core genes for simulation-based growth-coupled production. You can also see minimal gene deletions.

Model : e_coli_core [2].
Target metabolite : etoh_c
Core genes for growth-coupled production (at least stoichioemetrically feasible)
  #Remaining genes : 75
  Remaining genes: b0351 b0118 b0116 b1478 b0720 b2779 b2097 b4152 b4154 b4153 b4151 b2416 b2415 b1611 b4122 b1612 b1779 b1101 b2417 b1621 b1297 b3870 b0809 b0811 b1761 b3213 b0875 b1136 b3236 b2463 b2281 b2277 b2280 b2286 b2287 b2284 b2276 b2282 b2279 b2283 b2285 b2288 b2278 b1602 b0451 b0114 b0115 b3916 b1723 b2579 b0902 b3952 b4025 b2926 b3612 b4395 b0755 b3493 b2987 b3956 b1676 b1854 b3386 b4301 b2914 b4090 b0722 b0724 b0723 b0729 b0008 b2464 b2465 b2935 b3919   (List of alternative genes)
  Computed by: AddGdel [1] (Step 1, Step 2)

When growth rate is maximized,
  Growth Rate : 0.059118 (mmol/gDw/h)
  Minimum Production Rate : 4.918204 (mmol/gDw/h)

 Substrate: (mmol/gDw/h)
  EX_glc__D_e : 10.000000
  EX_nh4_e : 0.322361
  EX_pi_e : 0.217479

Product: (mmol/gDw/h)
  EX_h_e : 20.467124
  EX_h2o_e : 6.888934
  EX_succ_e : 6.501318
  EX_pyr_e : 6.278572
  Auxiliary production reaction : 4.918204
  EX_etoh_e : 1.403394

Visualization
  1. Download JSON file.
  2. Go to Escher site [3].
  3. Select "Data > Load reaction data" and apply the downloaded file.

References
[1] Tamura, T. MetNetComp: Database for minimal and maximal gene deletion strategies for growth-coupled production of genome-scale metabolic networks, IEEE/ACM Transactions on Computational Biology and Bioinformatics, in press.
[2] Orth, J. D., Fleming, R. M., Palsson, B. Ø. (2010). Reconstruction and use of microbial metabolic networks: the core Escherichia coli metabolic model as an educational guide. EcoSal plus, 4(1).
[3] King, Z. A., Dräger, A., Ebrahim, A., Sonnenschein, N., Lewis, N. E., & Palsson, B. O. (2015). Escher: a web application for building, sharing, and embedding data-rich visualizations of biological pathways. PLoS computational biology, 11(8), e1004321.

Last updated: 27-Sep-2023
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