MetNetComp Database [1] / Minimal gene deletions Minimal gene deletions for simulation-based growth-coupled production. You can also see maximal gene deletions.

Model : iLB1027_lipid [2].
Target metabolite : cbasp_c
List of minimal gene deletion strategies (Download)

Gene deletion strategy (12 of 34: See next) for growth-coupled production (at least stoichioemetrically feasible)
  Gene deletion size : 9
  Gene deletion: PHATRDRAFT_10257 PHATRDRAFT_draft870 PHATRDRAFT_10073 PHATRDRAFT_26290 PHATRDRAFT_31906 PHATRDRAFT_20310 PHATRDRAFT_52223 PHATRDRAFT_10409 PHATRDRAFT_48886   (List of alternative genes)
  Computed by: RandTrimGdel [1] (Step 1, Step 2)

When growth rate is maximized,
  Growth Rate : 0.316134 (mmol/gDw/h)
  Minimum Production Rate : 0.106384 (mmol/gDw/h)

Substrate: (mmol/gDw/h)
  EX_photon_e : 339.207592
  EX_h2o_e : 33.160676
  EX_co2_e : 32.655740
  EX_no3_e : 1.760000
  EX_pi_e : 0.078498
  EX_so4_e : 0.056221
  EX_mg2_e : 0.005650

Product: (mmol/gDw/h)
  EX_o2_e : 38.852274
  SK_for_c : 8.113190
  EX_h_e : 6.421825
  EX_etoh_e : 4.496906
  DM_biomass_c : 0.316134
  Auxiliary production reaction : 0.106384

Visualization
  1. Download JSON file.
  2. Go to Escher site [3].

References
[1] Tamura, T. MetNetComp: Database for minimal and maximal gene deletion strategies for growth-coupled production of genome-scale metabolic networks, IEEE/ACM Transactions on Computational Biology and Bioinformatics, in press.
[2] Norsigian, C. J., Pusarla, N., McConn, J. L., Yurkovich, J. T., Dräger, A., Palsson, B. O., & King, Z. (2020). BiGG Models 2020: multi-strain genome-scale models and expansion across the phylogenetic tree. Nucleic acids research, 48(D1), D402-D406.
[3] King, Z. A., Dräger, A., Ebrahim, A., Sonnenschein, N., Lewis, N. E., & Palsson, B. O. (2015). Escher: a web application for building, sharing, and embedding data-rich visualizations of biological pathways. PLoS computational biology, 11(8), e1004321.

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Last updated: 27-Sep-2023
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