MetNetComp Database [1] / Minimal gene deletions Minimal gene deletions for simulation-based growth-coupled production. You can also see maximal gene deletions.

Model : iLB1027_lipid [2].
Target metabolite : ethamp_c
List of minimal gene deletion strategies (Download)

Gene deletion strategy (14 of 25: See next) for growth-coupled production (at least stoichioemetrically feasible)
  Gene deletion size : 28
  Gene deletion: PHATRDRAFT_20342 PHATRDRAFT_27726 PHATRDRAFT_800 PHATRDRAFT_12902 Phatr3_EG02232 PHATRDRAFT_49601 PHATRDRAFT_55126 PHATRDRAFT_22404 PHATRDRAFT_3046 PHATRDRAFT_34120 PHATRDRAFT_45017 PHATRDRAFT_29016 PHATRDRAFT_14762 Phatr3_EG02361 PHATRDRAFT_41063 PHATRDRAFT_33839 PHATRDRAFT_859 PHATRDRAFT_44546 PHATRDRAFT_11273 PHATRDRAFT_35566 PHATRDRAFT_21970 PHATRDRAFT_42245 PHATRDRAFT_39772 PHATRDRAFT_43697 PHATRDRAFT_45428 PHATRDRAFT_12452 Phatr3_EG02611 PHATRDRAFT_41686   (List of alternative genes)
  Computed by: RandTrimGdel [1] (Step 1, Step 2)

When growth rate is maximized,
  Growth Rate : 0.111317 (mmol/gDw/h)
  Minimum Production Rate : 0.101910 (mmol/gDw/h)

Substrate: (mmol/gDw/h)
  EX_photon_e : 354.228168
  EX_co2_e : 31.209854
  EX_h2o_e : 24.364978
  EX_no3_e : 1.760000
  EX_pi_e : 0.129551
  EX_so4_e : 0.059117
  EX_mg2_e : 0.001989

Product: (mmol/gDw/h)
  EX_o2_e : 28.749775
  SK_for_c : 16.432354
  EX_h_e : 14.441051
  DM_indole_c : 1.113277
  DM_biomass_c : 0.111317
  Auxiliary production reaction : 0.101910
  EX_etoh_e : 0.091565
  DM_dmsp_c : 0.039320

Visualization
  1. Download JSON file.
  2. Go to Escher site [3].

References
[1] Tamura, T. MetNetComp: Database for minimal and maximal gene deletion strategies for growth-coupled production of genome-scale metabolic networks, IEEE/ACM Transactions on Computational Biology and Bioinformatics, in press.
[2] Norsigian, C. J., Pusarla, N., McConn, J. L., Yurkovich, J. T., Dräger, A., Palsson, B. O., & King, Z. (2020). BiGG Models 2020: multi-strain genome-scale models and expansion across the phylogenetic tree. Nucleic acids research, 48(D1), D402-D406.
[3] King, Z. A., Dräger, A., Ebrahim, A., Sonnenschein, N., Lewis, N. E., & Palsson, B. O. (2015). Escher: a web application for building, sharing, and embedding data-rich visualizations of biological pathways. PLoS computational biology, 11(8), e1004321.

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Last updated: 27-Sep-2023
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