MetNetComp Database [1] / Minimal gene deletions

Minimal gene deletions for simulation-based growth-coupled production. You can also see maximal gene deletions.

Model : iLB1027_lipid [2].
Target metabolite : mgdg1619Z162n4_h
List of minimal gene deletion strategies (Download)

Gene deletion strategy (43 of 57: See next) for growth-coupled production (at least stoichioemetrically feasible)
  Gene deletion size : 16
  Gene deletion: PHATRDRAFT_800 PHATRDRAFT_8691 PHATRDRAFT_29016 PHATRDRAFT_14401 PHATRDRAFT_31906 PHATRDRAFT_draft348 PHATRDRAFT_50742 Phatr3_EG02361 PHATRDRAFT_11414 PHATRDRAFT_52223 PHATRDRAFT_21970 PHATRDRAFT_22117 PHATRDRAFT_43697 PHATRDRAFT_8945 PHATRDRAFT_41686 PHATRDRAFT_46728   (List of alternative genes)
  Computed by: RandTrimGdel [1] (Step 1, Step 2)

When growth rate is maximized,
  Growth Rate : 0.344464 (mmol/gDw/h)
  Minimum Production Rate : 1.512445 (mmol/gDw/h)

 Substrate: (mmol/gDw/h)
  EX_photon_e : 1000.000000
  EX_co2_e : 83.544403
  EX_h2o_e : 71.740784
  EX_no3_e : 1.760000
  EX_pi_e : 0.085533
  EX_so4_e : 0.061260
  EX_mg2_e : 0.006156

Product: (mmol/gDw/h)
  EX_o2_e : 106.921496
  SK_for_c : 4.896880
  EX_h_e : 3.012770
  Auxiliary production reaction : 1.512445
  DM_biomass_c : 0.344464
  DM_fald_m : 0.027699
  SK_5mthglu_c : 0.008235

Visualization
  1. Download JSON file.
  2. Go to Escher site [3].

References
[1] Tamura, T. MetNetComp: Database for minimal and maximal gene deletion strategies for growth-coupled production of genome-scale metabolic networks, IEEE/ACM Transactions on Computational Biology and Bioinformatics, in press.
[2] Norsigian, C. J., Pusarla, N., McConn, J. L., Yurkovich, J. T., Dräger, A., Palsson, B. O., & King, Z. (2020). BiGG Models 2020: multi-strain genome-scale models and expansion across the phylogenetic tree. Nucleic acids research, 48(D1), D402-D406.
[3] King, Z. A., Dräger, A., Ebrahim, A., Sonnenschein, N., Lewis, N. E., & Palsson, B. O. (2015). Escher: a web application for building, sharing, and embedding data-rich visualizations of biological pathways. PLoS computational biology, 11(8), e1004321.

Last updated: 27-Sep-2023
Contact