MetNetComp Database [1] / Minimal gene deletions

Minimal gene deletions for simulation-based growth-coupled production. You can also see maximal gene deletions.

Model : iLB1027_lipid [2].
Target metabolite : na1_m
List of minimal gene deletion strategies (Download)

Gene deletion strategy (18 of 35: See next) for growth-coupled production (at least stoichioemetrically feasible)
  Gene deletion size : 11
  Gene deletion: PHATRDRAFT_51092 PHATRDRAFT_12031 PHATRDRAFT_44906 PHATRDRAFT_30145 PHATRDRAFT_55192 PHATRDRAFT_12762 PHATRDRAFT_21988 PHATRDRAFT_34120 PHATRDRAFT_49339 PHATRDRAFT_45239 PHATRDRAFT_43697   (List of alternative genes)
  Computed by: RandTrimGdel [1] (Step 1, Step 2)

When growth rate is maximized,
  Growth Rate : 0.359607 (mmol/gDw/h)
  Minimum Production Rate : 19.624007 (mmol/gDw/h)

 Substrate: (mmol/gDw/h)
  EX_photon_e : 1000.000000
  EX_na1_e : 837.237193
  EX_co2_e : 68.959225
  EX_h2o_e : 64.457732
  EX_no3_e : 1.760000
  EX_pi_e : 0.220000
  EX_so4_e : 0.135840
  EX_mg2_e : 0.006427

Product: (mmol/gDw/h)
  Auxiliary production reaction : 837.237193
  EX_o2_e : 66.332881
  EX_h_e : 21.245050
  EX_glyclt_e : 17.989172
  EX_lac__D_e : 5.017237
  DM_biomass_c : 0.359607
  SK_for_c : 0.306368
  DM_dmsp_c : 0.071888
  DM_fald_m : 0.050801
  DM_minohp_c : 0.021784

Visualization
  1. Download JSON file.
  2. Go to Escher site [3].

References
[1] Tamura, T. MetNetComp: Database for minimal and maximal gene deletion strategies for growth-coupled production of genome-scale metabolic networks, IEEE/ACM Transactions on Computational Biology and Bioinformatics, in press.
[2] Norsigian, C. J., Pusarla, N., McConn, J. L., Yurkovich, J. T., Dräger, A., Palsson, B. O., & King, Z. (2020). BiGG Models 2020: multi-strain genome-scale models and expansion across the phylogenetic tree. Nucleic acids research, 48(D1), D402-D406.
[3] King, Z. A., Dräger, A., Ebrahim, A., Sonnenschein, N., Lewis, N. E., & Palsson, B. O. (2015). Escher: a web application for building, sharing, and embedding data-rich visualizations of biological pathways. PLoS computational biology, 11(8), e1004321.

Last updated: 27-Sep-2023
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