MetNetComp Database [1] / Minimal gene deletions

Minimal gene deletions for simulation-based growth-coupled production. You can also see maximal gene deletions.

Model : iML1515 [2].
Target metabolite : adn_c
List of minimal gene deletion strategies (Download)

Gene deletion strategy (51 of 87: See next) for growth-coupled production (at least stoichioemetrically feasible)
  Gene deletion size : 28
  Gene deletion: b2836 b4382 b4384 b3708 b3008 b0871 b2925 b2097 b0030 b2407 b1982 b2797 b3117 b1814 b4471 b3946 b0825 b2406 b2868 b0114 b0886 b2366 b2492 b0904 b1533 b3927 b3662 b1517   (List of alternative genes)
  Computed by: RandTrimGdel [1] (Step 1, Step 2)

When growth rate is maximized,
  Growth Rate : 0.774641 (mmol/gDw/h)
  Minimum Production Rate : 0.092723 (mmol/gDw/h)

 Substrate: (mmol/gDw/h)
  EX_o2_e : 24.698966
  EX_glc__D_e : 10.000000
  EX_nh4_e : 9.088207
  EX_pi_e : 0.747223
  EX_so4_e : 0.195070
  EX_k_e : 0.151204
  EX_fe2_e : 0.012442
  EX_mg2_e : 0.006720
  EX_ca2_e : 0.004032
  EX_cl_e : 0.004032
  EX_cu2_e : 0.000549
  EX_mn2_e : 0.000535
  EX_zn2_e : 0.000264
  EX_ni2_e : 0.000250
  EX_cobalt2_e : 0.000019

Product: (mmol/gDw/h)
  EX_h2o_e : 47.984401
  EX_co2_e : 25.990730
  EX_h_e : 7.839861
  EX_acser_e : 0.256449
  Auxiliary production reaction : 0.092723
  EX_hxan_e : 0.000521
  EX_mththf_e : 0.000347
  DM_5drib_c : 0.000174
  DM_4crsol_c : 0.000173

Visualization
  1. Download JSON file.
  2. Go to Escher site [3].
  3. Select "Data > Load reaction data" and apply the downloaded file.

References
[1] Tamura, T. MetNetComp: Database for minimal and maximal gene deletion strategies for growth-coupled production of genome-scale metabolic networks, IEEE/ACM Transactions on Computational Biology and Bioinformatics, in press.
[2] Norsigian, C. J., Pusarla, N., McConn, J. L., Yurkovich, J. T., Dräger, A., Palsson, B. O., & King, Z. (2020). BiGG Models 2020: multi-strain genome-scale models and expansion across the phylogenetic tree. Nucleic acids research, 48(D1), D402-D406.
[3] King, Z. A., Dräger, A., Ebrahim, A., Sonnenschein, N., Lewis, N. E., & Palsson, B. O. (2015). Escher: a web application for building, sharing, and embedding data-rich visualizations of biological pathways. PLoS computational biology, 11(8), e1004321.

Last updated: 21-Sep-2023
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