MetNetComp Database [1] / Minimal gene deletions

Minimal gene deletions for simulation-based growth-coupled production. You can also see maximal gene deletions.

Model : iML1515 [2].
Target metabolite : gdpmann_c
List of minimal gene deletion strategies (Download)

Gene deletion strategy (49 of 108: See next) for growth-coupled production (at least stoichioemetrically feasible)
  Gene deletion size : 28
  Gene deletion: b3399 b4382 b1241 b0351 b4069 b2502 b2744 b3708 b2297 b2458 b3617 b1982 b2797 b3117 b1814 b4471 b0675 b2361 b0261 b4381 b2406 b0112 b0114 b2366 b2492 b0904 b1533 b3821   (List of alternative genes)
  Computed by: RandTrimGdel [1] (Step 1, Step 2)

When growth rate is maximized,
  Growth Rate : 0.550340 (mmol/gDw/h)
  Minimum Production Rate : 0.809014 (mmol/gDw/h)

 Substrate: (mmol/gDw/h)
  EX_o2_e : 21.536278
  EX_glc__D_e : 10.000000
  EX_nh4_e : 9.988698
  EX_pi_e : 2.148889
  EX_so4_e : 0.138587
  EX_k_e : 0.107423
  EX_fe2_e : 0.008839
  EX_mg2_e : 0.004774
  EX_ca2_e : 0.002865
  EX_cl_e : 0.002865
  EX_cu2_e : 0.000390
  EX_mn2_e : 0.000380
  EX_zn2_e : 0.000188
  EX_ni2_e : 0.000178
  EX_cobalt2_e : 0.000014

Product: (mmol/gDw/h)
  EX_h2o_e : 46.142957
  EX_co2_e : 20.283798
  EX_h_e : 9.574694
  EX_ac_e : 2.090906
  Auxiliary production reaction : 0.809014
  DM_5drib_c : 0.000369
  DM_4crsol_c : 0.000123

Visualization
  1. Download JSON file.
  2. Go to Escher site [3].
  3. Select "Data > Load reaction data" and apply the downloaded file.

References
[1] Tamura, T. MetNetComp: Database for minimal and maximal gene deletion strategies for growth-coupled production of genome-scale metabolic networks, IEEE/ACM Transactions on Computational Biology and Bioinformatics, in press.
[2] Norsigian, C. J., Pusarla, N., McConn, J. L., Yurkovich, J. T., Dräger, A., Palsson, B. O., & King, Z. (2020). BiGG Models 2020: multi-strain genome-scale models and expansion across the phylogenetic tree. Nucleic acids research, 48(D1), D402-D406.
[3] King, Z. A., Dräger, A., Ebrahim, A., Sonnenschein, N., Lewis, N. E., & Palsson, B. O. (2015). Escher: a web application for building, sharing, and embedding data-rich visualizations of biological pathways. PLoS computational biology, 11(8), e1004321.

Last updated: 21-Sep-2023
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