MetNetComp Database [1] / Minimal gene deletions

Minimal gene deletions for simulation-based growth-coupled production. You can also see maximal gene deletions.

Model : iMM904 [2].
Target metabolite : cdpea_c
List of minimal gene deletion strategies (Download)

Gene deletion strategy (39 of 69: See next) for growth-coupled production (at least stoichioemetrically feasible)
  Gene deletion size : 28
  Gene deletion: YBR068C YMR083W YDR046C YBR069C YGR087C YLR044C YLR134W YDR380W YMR009W YOR348C YKL192C YBR291C YHR002W YPL265W YCL025C YKR039W YOL020W YOR120W YOL059W YGR191W YLR231C YJL121C YLR348C YPL092W YML120C YEL046C YDR402C YFR047C   (List of alternative genes)
  Computed by: RandTrimGdel [1] (Step 1, Step 2)

When growth rate is maximized,
  Growth Rate : 0.125607 (mmol/gDw/h)
  Minimum Production Rate : 0.136704 (mmol/gDw/h)

 Substrate: (mmol/gDw/h)
  EX_glc__D_e : 10.000000
  EX_o2_e : 2.000000
  EX_nh4_e : 1.285756
  EX_pi_e : 0.312636
  EX_so4_e : 0.009709

Product: (mmol/gDw/h)
  EX_h_e : 20.308020
  EX_h2o_e : 13.940370
  EX_succ_e : 6.744090
  EX_pyr_e : 6.014665
  EX_iamoh_e : 1.485948
  EX_2mbtoh_e : 0.291796
  Auxiliary production reaction : 0.136704
  EX_pap_e : 0.007197
  EX_for_e : 0.000649

Visualization
  1. Download JSON file.
  2. Go to Escher site [3].
  3. Select "Data > Load reaction data" and apply the downloaded file.

References
[1] Tamura, T. MetNetComp: Database for minimal and maximal gene deletion strategies for growth-coupled production of genome-scale metabolic networks, IEEE/ACM Transactions on Computational Biology and Bioinformatics, in press.
[2] Norsigian, C. J., Pusarla, N., McConn, J. L., Yurkovich, J. T., Dräger, A., Palsson, B. O., & King, Z. (2020). BiGG Models 2020: multi-strain genome-scale models and expansion across the phylogenetic tree. Nucleic acids research, 48(D1), D402-D406.
[3] King, Z. A., Dräger, A., Ebrahim, A., Sonnenschein, N., Lewis, N. E., & Palsson, B. O. (2015). Escher: a web application for building, sharing, and embedding data-rich visualizations of biological pathways. PLoS computational biology, 11(8), e1004321.

Last updated: 27-Sep-2023
Contact