MetNetComp Database [1] / Minimal gene deletions

Minimal gene deletions for simulation-based growth-coupled production. You can also see maximal gene deletions.

Model : iMM904 [2].
Target metabolite : udpg_c
List of minimal gene deletion strategies (Download)

Gene deletion strategy (95 of 104: See next) for growth-coupled production (at least stoichioemetrically feasible)
  Gene deletion size : 28
  Gene deletion: YDL168W YMR303C YBR068C YDR046C YBR069C YDR035W YGR087C YFL053W YML070W YLR044C YLR134W YDR380W YDL080C YKL192C YHR002W YJL060W YCL025C YKR039W YOL020W YOL059W YGR191W YJL121C YLR348C YLR017W YML120C YEL046C YDR402C YFR047C   (List of alternative genes)
  Computed by: RandTrimGdel [1] (Step 1, Step 2)

When growth rate is maximized,
  Growth Rate : 0.107534 (mmol/gDw/h)
  Minimum Production Rate : 0.116896 (mmol/gDw/h)

 Substrate: (mmol/gDw/h)
  EX_glc__D_e : 10.000000
  EX_o2_e : 2.000000
  EX_nh4_e : 0.866968
  EX_pi_e : 0.267374
  EX_so4_e : 0.008312

Product: (mmol/gDw/h)
  EX_h_e : 21.949024
  EX_h2o_e : 13.551185
  EX_succ_e : 6.933221
  EX_3c3hmp_e : 3.307598
  EX_pyr_e : 0.645003
  EX_3mop_e : 0.249533
  Auxiliary production reaction : 0.116896
  EX_pap_e : 0.006162
  EX_gly_e : 0.000558
  EX_for_e : 0.000556

Visualization
  1. Download JSON file.
  2. Go to Escher site [3].
  3. Select "Data > Load reaction data" and apply the downloaded file.

References
[1] Tamura, T. MetNetComp: Database for minimal and maximal gene deletion strategies for growth-coupled production of genome-scale metabolic networks, IEEE/ACM Transactions on Computational Biology and Bioinformatics, in press.
[2] Norsigian, C. J., Pusarla, N., McConn, J. L., Yurkovich, J. T., Dräger, A., Palsson, B. O., & King, Z. (2020). BiGG Models 2020: multi-strain genome-scale models and expansion across the phylogenetic tree. Nucleic acids research, 48(D1), D402-D406.
[3] King, Z. A., Dräger, A., Ebrahim, A., Sonnenschein, N., Lewis, N. E., & Palsson, B. O. (2015). Escher: a web application for building, sharing, and embedding data-rich visualizations of biological pathways. PLoS computational biology, 11(8), e1004321.

Last updated: 27-Sep-2023
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