MetNetComp Database [1] / Minimal gene deletions

Minimal gene deletions for simulation-based growth-coupled production. You can also see maximal gene deletions.

Model : iPC815 [2].
Target metabolite : apg141_c
List of minimal gene deletion strategies (Download)

Gene deletion strategy (22 of 34: See next) for growth-coupled production (at least stoichioemetrically feasible)
  Gene deletion size : 25
  Gene deletion: YPO1384 YPO4078 YPO3825 YPO3937 YPO3949 YPO3428 YPO0348 YPO0253 YPO3992 YPO0347 YPO3202 YPO3516 YPO1145 YPO3014 YPO0670 YPO2303 YPO3914 YPO0440 YPO1851 YPO3418 YPO2370 YPO0921 YPO1133 YPO2567 YPO1171   (List of alternative genes)
  Computed by: RandTrimGdel [1] (Step 1, Step 2)

When growth rate is maximized,
  Growth Rate : 0.096504 (mmol/gDw/h)
  Minimum Production Rate : 0.081444 (mmol/gDw/h)

 Substrate: (mmol/gDw/h)
  EX_h_e : 9.230279
  EX_cit_e : 7.400000
  EX_o2_e : 4.508968
  EX_gly_e : 2.200000
  EX_cys__L_e : 1.000000
  EX_glc__D_e : 0.227216
  EX_pi_e : 0.160453
  EX_lys__L_e : 0.024126
  EX_phe__L_e : 0.018336
  EX_met__L_e : 0.013511
  EX_tyr__L_e : 0.012546

Product: (mmol/gDw/h)
  EX_co2_e : 14.899953
  EX_succ_e : 7.400000
  EX_h2o_e : 5.717107
  EX_nh4_e : 2.110936
  EX_h2s_e : 0.992949
  EX_ac_e : 0.410000
  EX_glyald_e : 0.081953
  Auxiliary production reaction : 0.081444

Visualization
  1. Download JSON file.
  2. Go to Escher site [3].

References
[1] Tamura, T. MetNetComp: Database for minimal and maximal gene deletion strategies for growth-coupled production of genome-scale metabolic networks, IEEE/ACM Transactions on Computational Biology and Bioinformatics, in press.
[2] Norsigian, C. J., Pusarla, N., McConn, J. L., Yurkovich, J. T., Dräger, A., Palsson, B. O., & King, Z. (2020). BiGG Models 2020: multi-strain genome-scale models and expansion across the phylogenetic tree. Nucleic acids research, 48(D1), D402-D406.
[3] King, Z. A., Dräger, A., Ebrahim, A., Sonnenschein, N., Lewis, N. E., & Palsson, B. O. (2015). Escher: a web application for building, sharing, and embedding data-rich visualizations of biological pathways. PLoS computational biology, 11(8), e1004321.

Last updated: 27-Sep-2023
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